Category Archives: Biotech

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Enabling microRNA Discoveries – 250th Peer-Reviewed Publication Made Possible By µparaflo Custom Microarray Technology

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LC Sciences, a life sciences company leading the development of innovative microRNA (miRNA) analysis and discovery technologies, announced today the publication of over 250 peer-reviewed studies using the company’s microarray service for analyzing miRNA expression profiles. These studies, by leading researchers in the field, represent significant steps toward realizing these small regulatory RNA’s potential as biomarkers and therapeutic targets.

MiRNAs have proven to be an extremely important part of the gene expression regulation mechanism of a wide variety of cellular processes. This is evident in the amount of relevant findings by LC Sciences’ customers being translated into published reports and the diverse range of study areas that these publications encompass: cancer research, neuroscience, cardiovascular research, reproductive biology, plant science, microbiology, immunology and stem cell research. LC Sciences’ miRNA profiling service, powered by its µParaflo® custom microarray technology, provides quick, reliable, fully analyzed datasets enabling researchers to immediately move forward with groundbreaking research.

The miRNA field is still nascent, and it is advancing rapidly. The race to discovery has produced a continuous stream of new miRNA sequences as well as routine revisions of inaccurate or incomplete sequences. This fluidity has caused many microarrays with static content to fall away and has fueled reports of the wholesale replacement of microarrays by new methods such as RNA-Seq. But the nimble, customizable format of the µParaflo® array has given it staying power, not only by enabling it to keep current with all known miRNAs, but also by making use of data generated by RNA-Seq. These custom arrays have benefited from RNA-sequencing generating novel content that other arrays are unable to capture and take advantage of.

The 250th study, entitled “Wolbachia uses host microRNAs to manipulate host gene expression and facilitate colonization of the dengue vector Aedes aegypti.” appeared in the May 31st issue of PNAS and was one of a group of articles published recently by LC Sciences’ customers describing microarray expression analysis of miRNAs recently discovered through RNA Sequencing.

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New Report on Fighting Chronic Disease Examines the Importance of Non-Communicable Diseases in Global Health Care

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In the first of a series of new reports, a coalition of pharmaceutical industry trade organizations outlines the serious burden that chronic diseases place on patients and global health care systems.“Fighting Chronic Disease: Importance of Non-communicable Diseases” is the first of four reports that look at this growing issue for patients and health care systems around the world.

The report was compiled by the European Federation of the Pharmaceutical Industries and Associations, the International Federation of Pharmaceutical Manufacturers & Associations, the Japan Pharmaceutical Manufacturers Association, and the Pharmaceutical Researchers and Manufacturers Association. Together, these organizations highlight the powerful role that public-private partnerships can play in mitigating the burden of chronic disease. Non-communicable diseases like stroke, heart disease, diabetes, and cancers can often strain global health care resources, and targeting the main risk factors of these conditions can significantly reduce the burden of these diseases worldwide.

Most NCDs are preventable because they are caused by modifiable risk factors, which include poor diet, lack of physical activity and tobacco use. Every year, more than 5 million people die because of direct tobacco use and 2.8 million die from being overweight or obese. High cholesterol accounts for 2.6 million deaths and 7.5 million die because of elevated blood pressure. Individually, chronic disease lowers quality of life for those affected, causes premature deaths and negatively impacts the economic solvency of families, communities and nations. Interventions that focus on better diet, increased physical activity and access to vaccines have been proven to decrease the incidence of chronic disease and improve quality of life.

The pharmaceutical industry has long recognized the economic and social burden of non-communicable diseases (NCDs) and has been working with governments, health care providers, patients groups and other stakeholders as an active solution partner in lessening this burden. The industry promotes and supports health prevention and promotion strategies and patient-centered approaches to managing chronic conditions and their risk factors. At the same time the global biopharmaceutical industry leads the search for new cures and the research and development of new medicines to treat or prevent non-communicable diseases. There are currently thousands of medicines either in clinical trials or awaiting approval to treat NCDs. The great challenge in preventing and controlling NCDs on a global scale is finding patient-centered solutions that reduce the burden on global health care services by promoting individual healthy lifestyles.

The R&D-based pharmaceutical industry works to improve the health and quality of life of all patients, and is committed to continuing partnerships that tackle these complex issues including extensive investment in R&D programs dedicated to the development of new NCD preventative and treatment products. Both prevention and treatment play an important role in addressing the problem of non-communicable diseases.

The full report is available at
http://globalhealthprogress.org/mediacenter/index.php/new-report-examines…

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Will the Catholic Church & the U.S. Courts Embrace Advanced Cell Technologies “Embryo-Safe” Technique Using Embryonic Stem Cells?

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Advanced Cell Technology with laboratory facilities in Marlborough Massachusetts has pioneered a solution to the ethical, moral & legal debate raging in regards to protection of a human embryo. ACT has developed the “single-blastomere” technique. Patent Number 7,893,315 a non-destructive alternative for deriving human embryonic stem cell (hESC) lines.

This achievement in Regenerative medicine is a ground breaking feat for both Catholic and U.S. law.
• The 1995 encyclical The Gospel of Life, of which Pope John Paul II wrote: “Human embryos obtained in vitro are human beings and are subjects with rights; their dignity and right to life must be respected from the first moment of their existence. It is immoral to produce human embryos destined to be exploited as disposable ‘biological material'” (1,5 )
• The Dickey Amendment (also known as the Dickey-Wicker Amendment) is the name of an appropriation bill rider attached to a bill passed by United States Congress in 1995, and signed by former President Bill Clinton, which prohibits the Department of Health and Human Services (HHS) from using appropriated funds for the creation of human embryos for research purposes or for research in which human embryos are destroyed.

The single-blastomere technology uses a one-cell biopsy approach similar to pre-implantation genetic diagnosis (PGD), which is widely used in the in vitro fertilization (IVF) process and does not interfere with the embryo’s developmental potential. The stem cells generated using this approach are healthy, completely normal, and differentiate into all the cell types of the human The safety record for one-cell biopsy as part of PGD now has a 15-year track record, and is carried out routinely as part of IVF processes around the world. ACT’s technique of protecting the human embryo from harm can be expounded to the smallest blood transfusion in the world. As does a human being give millions of blood cells in a pint of blood so does ACT’s “single blastomere” process take but “one cell” from a 2 day old embryo. As the blood removed from a human donor “regenerate” the removed pint of blood so does the human embryo “regenerate” the one cell. Both of these procedures leave the human body & two day old embryo healthy. Both procedures are similar in that they both provide life saving material to those whom need them most to due to disease and other aliments of a medical nature.

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Global Health Progress Releases Non-Communicable Diseases Partnerships and Programs List

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Global Health Progress compiled a list of non-communicable disease treatment programs from around the world, highlighting partnerships to address cancer treatment, diabetes care, epilepsy programs and more. The programs, sponsored by leading companies like Astra Zeneca, Abbott, Novo Nordisk, and Bayer Healthcare, aim to increase awareness of non-communicable diseases in the developing world.

“Our goal in creating this list is to bring awareness to these companies who work so hard at fighting diseases in developing countries,” explains Mark Grayson, Vice President of Communications and Public Affairs at PhRMA and key developer in the Global Health Progress initiative. “Non-communicable diseases are the leading killer in many of these countries, and without the help of these programs they would continue to increase.”

Global Health Progress works with partner groups to encourage and sustain funding for the research and development of healthcare in developing nations. Improving health care systems and access to medicines, especially in the developing world, requires multifaceted approaches and solutions. Research-based biopharmaceutical companies are active partners in some of the largest and boldest health initiatives that explore new and effective ways to provide treatment, care and education to millions of people in developing countries.

Read the full list of non-communicable disease treatment programs here:
http://globalhealthprogress.org/mediacenter/wp-content/uploads/NCD-Health-Partnerships-and-Programs_Worldwide-05-02-11.pdf.

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Side by side comparison of Advanced Cell Technology & Geron Corporation

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Regenerative medicine is a highly complicated and vastly misunderstood science. Investor Stem Cell is dedicated to bringing investors and stakeholders together in thoughtful discussion to educate and publicize the incredible advancements unfolding in the regenerative medicine sector. A quantum leap in health care is upon the world. Will you profit from this emerging sector & help bring cures to millions? Find out now what the street thinks at www.investorstemcell.com.

Side by side comparison of Advanced Cell Technology & Geron Corporation:

Geron Corporation (NASDAQ:GERN), Approved by the FDA to use human embryonic stem cell (hESC) treatments to treat spinal cord injuries. The research Goliath is a well-funded machine employing the top minds in the world working on everything from mid-stage oncology trials to promising (hESC) drugs for spinal cord injuries, heart disease & cancer.

Snap shot of Goliath: Geron Corpoartion-(NASDAQ:GERN)-
• Seven oncology Phase 2 trials currently underway, and has several big Pharma joint venture agreements in oncology animal and human trials
• Five hESC areas of investigation underway. GRNOPC1 is the lead candidate. Geron destroys the human embryo through its (hESC) R&D, of which the company uses the blastocyst embryo formation at day five after fertilization from IVF clinics
• Cash, restricted cash, cash equivalents and marketable securities: $221,274.000.00
• Total operating expenses in 2010: $114,730,000.00
• 175 employees; over 100 hold PhD or MD degrees
• Geron Corporation was founded in 1990 and is based in Menlo Park, California
• Trades on the NASDAQ providing liquidity & large institutional investors
• Corporate financial statements:http://www.geron.com/investors/reports/GeronAnnualReport2010.pdf

Advanced Cell Technology not too long ago was the predominant leader in the field of regenerative medicine. It fell from that distinction in part due to executive management hubris and ultimately the credit crisis in mid-2008. ACT was able to resurrect itself from near bankruptcy in June 2008 and now has the distinction of holding two out of the three FDA approved (hESC) trials. ACT is led by a competent executive management team and employs several of the most predominant regenerative researcher(s) in the world.

Snap shot of David: Advanced Cell Technology-(OTC:ACTC)-
• Retinal Pigment Epithelial Cell Program is their lead program-(HESC) trials for both SMD/AMD are expected to start in week(s) Jules Stein Eye Institute at the University of California, Los Angeles (UCLA ) will conduct the 2 (hESC) trials for Stargardt’s Macular Dystrophy (SMD) and Dry Age-Related Macular Degeneration (AMD)
• Filed a European Clinical Trial Application for Phase 1/2 study using (hESC) to treat macular degeneration
• Issued a broad patent for hESC-derived RPE cells in China
• Seeking funding & joint venture partner for Myoblast program for the treatment of cardiovascular disease Phase 2 approved by the FDA
• Joint ventured with Korean medical giant CHA to form “Stem Cell & Regenerative Medicine International” (SCRMI). This partnership expected to file an investigational new drug application (IND) with the FDA in Q-4 of this year. CHA biotech is waiting for final approval from the Korea Food and Drug Administration for (hESC) trial for AMD
• Issued patent on its “single-blastomere” technique. Patent Number 7,893,315 broadly covers ACT’s proprietary single-blastomere technology that provides a non-destructive alternative for deriving hESC lines. This “Embryo-Safe” one-cell biopsy approach similar to pre-implantation genetic diagnosis (PGD), which is widely used in the in vitro fertilization (IVF) process and does not interfere with the embryo’s developmental potential
• 22 full-time employees, six hold PhD or MD degrees-Formed in 1994, HQ in Menlo Park, California with laboratory facilities in Marlborough, MA
• Total operating expenses in 2010: $22,044,701
• Cash, restricted cash, cash equivalents and marketable securities: $34,889,409
• Trades on the OTC:BB ACTC is a Sarbanes–Oxley Act SEC reporter
• Corporate financial statements: http://www.sec.gov/Archives/edgar/data/11...

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From Universal HIV Testing to HIV Cure

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People involved in the fight against HIV/AIDS will gather in Marseille, France, May 23-25, 2012 for an international AIDS Conference under the theme: ‘From Universal HIV Testing to HIV Cure’.

The ISHEID (International Symposium on HIV & Emerging Infectious Diseases) is a major scientific event attracting doctors, biologists, researchers, patients’ representatives and policy makers from all around the world. Its next edition, to be held just more than one year ahead, will focus on recent developments against this pandemic.

Despite major advances in antiretroviral therapy, HIV still infects daily 2,000 new individuals and kills 2 millions each year. Current treatments are life-long with problems of compliance, resistance, toxicity, access, and cost.

‘There are advances both in the area of prevention, testing and potential cure’ told Alain Lafeuillade, a French Doctor involved in the organization of the conference. ‘Our driving force is to draw to the conference the best experts in the world for each program theme’. Antiretroviral treatment as prevention (or pre-exposure prophylaxis) will be debated with the pros and cons. Human rights and access to HIV care will be the focus of en entire session. Current issues in antiretroviral therapy management will be discussed during 2 sessions. Finally, the best American experts in the field of HIV reservoirs and eradication research will present their latest discoveries in the search for a cure.

The international Steering Committee will actively build a program the most exciting possible in the forthcoming months. Meanwhile, interviews of renowned experts are regularly published on the meeting website: http://www.isheid.com/en/committees/interview.html

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New Website Dedicated To Stem Cell Investors

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Investor Stem Cell (http://www.investorstemcell.com) is dedicated to bringing investors and stakeholders together in thoughtful discussion to educate and publicize the incredible medical advancements taking place in the regenerative medicine sector. Scientists are using stem cells both (hESC) and (iPSC) in hopes of easing the suffering of hundreds of millions of people world wide.

Our society is on the verge of a quantum leap moment in time thanks to regenerative medicine.

Regenerative medicine and Stem Cell research:

Utter those words at your next dinner party or casual gathering of friends and family. You will receive a concoction of half-truth’s and out right fallacy responses. Stem Cell research conjures images of futuristic Star–Trek like preservation chambers, human looking ears protruding oddly from the backs of mice, or worse yet an image of a late term fetus. Nothing could be farther from the truth when entering the reality of Regenerative medicine.

Never before has this area of research been more exciting and promising than right now. There is a medical revolution brewing, and like any revolution, there are those who want to suppress this uprising for continued personal and ideological gains. If we were to take all the major advances in the past 500 years of human medical history and multiply its effect by 10 fold it still would not compare to the paradigm shift in health care delivery that the world may witness in this decade using stem cells. Imagine that an $800,000 heart transplant is no longer needed and that instead the same money spent on one patient can now be stretched out to treat 20 patients who are needing a heart transplant. Is this what Regenerative medicine has in the offing? Only time will tell. Our healthcare system could very well be on the verge of a quantum leap moment thanks to regenerative medicine.

The Food and Drug Administration (FDA) authorized 3 trials using human embryonic stem cells (hESC) in late 2010. Validation of hESC research efforts and the culmination of billions spent on research are coming to fruition. FDA validation for the treatments of spinal cord injury and age related macular degeneration is expected in 2011. It may be the shot heard around the world event sometime in late Q-4 2011 for the Regenerative medicine sector.

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Medical Innovation Protection Stressed in EU-India Free Trade Agreement Talks

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The Financial Express published an article on the Free Trade Agreement (FTA) talks that continue between the European Union (EU) and India. One of the most discussed and disagreed upon parts of the proposed FTA involves the need for protecting the intellectual property of pharmaceutical companies in order to promote medical innovation and investment in the development of new medicines and research. This disagreement about whether data exclusivity in the pharmaceutical sector should be included has resulted in the delay of finalizing the FTA.

Pharmaceutical companies rely on data exclusivity to protect the investment made in developing the medication that is used throughout the world. Millions of dollars are spent on clinical trials to prove the safety and effectiveness of these drugs. These exclusive rights prevent competitors from obtaining marketing licenses for lower cost versions of these drugs.

Global Health Progress (GHP) is committed to being part of the effort to create a sustainable health care system that includes improving access to health care and continuing medical innovation and progress for all people. While the pharma industry is divided on the issue, GHP supports efforts to improve regulations protecting pharmaceutical companies’ intellectual property. Without this protection, the funding of studies that bring these medications to market could suffer.

Improving health care systems and access to medicines, especially in the developing world, requires multifaceted approaches and solutions. Research-based biopharmaceutical companies are active partners in some of the largest and boldest health initiatives that explore new and effective ways to provide treatment, care and education to millions of people in developing countries.

About Global Health Progress:
Global Health Progress also supports efforts to raise awareness and mobilize resources to address health challenges in the developing world by bringing local leaders together with international health experts, policymakers, donor governments, and the private sector.

www.globalhealthprogress.org;

twitter.com/globalhealth;

facebook.com/pages/Global-Health-Progress/124850684219049;

linkedin.com/groups?home=&gid=2972068

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Global Health Progress Amplifies Report Calling for Funding Products to Fight Neglected Tropical Diseases

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The third-annual Global Funding of Innovation for Neglected Diseases (G-FINDER) survey was released last week revealing both good and bad news for the funding of neglected diseases in the developing world. In a press release issued by Policy Cures, an independent group providing research and analysis for those involved in the creation of new pharmaceuticals for neglected diseases, the group reveals that while funding for neglected diseases has increased, funding for new products has decreased.

Funders appear to be focusing more of their money toward traditional basic research. This shift has caused a $50 million drop in funding for Product Development Partnerships (PDP), non-profit organizations that partner with external organizations to drive product development for neglected diseases, including neglected tropical diseases.

Report author Dr Mary Moran, Director of Policy Cures warns funders not to “take their eyes off the ball” in the press release, stating that while the increase in funding is encouraging it is important that the funds are spent wisely.

Global Health Progress has worked with partner groups to encourage and sustain funding for the research and development of new products. The innovative research and development (R&D) of new drugs and vaccines is a critical component of improving health care and combating epidemics of neglected tropical diseases in developing countries. There are no vaccines or cures for some widespread and life threatening diseases such as malaria, while existing treatments for diseases such as tuberculosis are becoming less effective due to drug resistance.

Read the full press release from Policy Cures here:
http://globalhealthprogress.org/mediacenter/wp-content/uploads/G-FINDER_Year_3_media_release.pdf,
or read the G-FINDER report on the Policy Cures website:
http://www.policycures.org/downloads/g-finder_2010.pdf.

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Global Health Progress Encourages Global Partnerships on Access to Health Care

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Starting this month, members of Congress will be looking closely at U.S. spending as they work with the White House to build the 2012 budget. One area that has come under increased scrutiny is U.S. spending on global health programs. Several groups last week announced a petition (http://www.supportglobalhealth.org/) seeking support for global health spending through the United States Global Health Initiative. Many fear that even flat spending in this area could jeopardize important programs in vaccine research and treatment.

News like this highlights the important role that public-private partnerships play in supporting access to global health care. The Global Health Progress initiative seeks to bring research-based biopharmaceutical companies and global health leaders together to improve access to medicine and health care in the developing world. We are committed to being part of the effort to create a sustainable health care system that includes improving access to health care and continuing medical innovation and progress for all people.

Research-based biopharmaceutical companies and their partners around the world are working to implement sustainable solutions and strengthen the health care delivery systems so they can meet tomorrow’s challenges. Millions of people lack access to essential medicines due to factors including incomplete delivery systems, lack of training for health personnel, lack of infrastructure and the cost of treatments. We must address the underlying barriers to health care, such as weak and fragmented health systems, limited health care personnel and inadequate resources for scaling up proven solutions. The innovative research and development (R&D) of new drugs and vaccines is a critical component of improving health care and combating epidemics in developing countries.

Through meaningful public-private partnerships with others in the field, including policymakers in the developed and developing world, multi-lateral institutions, non-governmental organizations, and academia we can help shape sustainable solutions that improve the health of all people.

To stay informed on the latest news about global investment in pharmaceutical R&D and improving access to medicines, sign up to receive special alerts and newsletters. You can also spread the word about the efforts of the Global Health Progress initiative and keep others informed about how we’re affecting change around the world, or share your story about how you or someone you know is working to promote global health.

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Assay-Ready Chemistry Partnership between Molplex & Enamine

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Molplex and Enamine today announced a new partnership to offer the Enamine screening collection of 1.8 million stock chemicals through the Molplex online drug design and assay-ready chemical supply services. The agreement is a major step towards eliminating the high start-up costs ofdrug discovery, bringing sophisticated drug design, compound management and assay-ready chemistry to the world’s drug discovery scientists on demand.

The agreement adds Molplex online drug design systems to the deep experience in organic chemistry and compound management of Enamine to solve the problem of generating viable chemical leads for novel targets.

Molplex CEO David E. Leahy said: “We are very proud to be selected by Enamine as their partner for on demand drug discovery services at a time when major restructuring of the industry is creating new opportunities and new markets for our combined expertise. This agreement marks a step change in the size and scope of our assay-ready chemical supply service and major progress towards our goal of being the world’s first choice partner for enabling the long tail of drug discovery”

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Gene Therapy and Stem Cell Therapy Standard Developed For A Unique Derivative Of Post Hetero-Plastic Inplantation Chronic Inflammation Syndrome, The NIDO Disease

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Researchers task force, led by faculties of T-Protocol, registered Genom Project as controlled genom project in the hosted database of NCBI, a publication matter authority and function assigned organization under oversee of Department of Health & Human Services, reached once to share the exegetical impression officially pre-published concerning the understanding specific spectrum of symptoms covering boroad range of character usually complained and observed through chronic inflammation, granuloma, some types of lymphoma and various uncommon symptoms to let physician scientists suspecting indicium of neurological diseases, NIDO disease, an unique type of post hetero-plastic implantation chronic inflammation syndrome and setting Massachusetts indications of treatments standardized manual (Massachusetts manual) & diagnostic and standardized medical treatment manual for post hetero-plastic inplantation chronic inflammation syndrome, specific edition against NIDO Disease.

The once defined causes of NIDO disease, an unique type of post hetero-plastic implantation chronic inflammation syndrome are considered each of a common living organism to cause conformational diseases like Creutzfeldt-Jakob disease, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and kinds of and a set of biochemical and physical reaction and response realized by cross-species gene- mutation, as biotransformation, easily describing natural physiological and biochemical changes in vivo substrate of human bodies. After this studies, standardized protocol of gene therapy and applied stem cell therapy is now in practice and on available.

Faculties,committing themselves entirely to the project, of each institutes and organizations participating the project to ascertain proteins and DNA/genomic DNA/genom of human, other mammal and virulent microorganism including bacillus/virus affecting each symptom and the symptoms’ spectrum expressed generally and observed commonly on patients suffered from NIDO disease, extraordinarily unique derived type of post hetero-plastic implantation chronic inflammation syndrome and to develop diagnostic standard and treatment protocol standardized and to find a clue compose gene therapy protocol and applied stem cell therapy protocol to entirely heal NIDO disease, an unique type of post hetero-plastic implantation chronic inflammation syndrome and to let all of current suffered patients from various combined symptoms directly derived by chronic inflammation and various tumors, have to express full surprise at the fact that these disease and patients suffered are made up and left no attention and no relief.

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New UN Program Will Ensure Developing Nations Continue to Have Access to Drugs Effective At Treating Malaria

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Earlier this week, the United Nations announced a new plan of action designed to help fight disease resistance to artemisinin, the world’s most potent treatment for malaria. Launched by the UN World Health Organization (WHO) and the Roll Back Malaria Partnership (RBM), the groups hope to better contain and prevent resistance to artemisinins, the critical component of artemisinin-based combination therapies (ACTs), which are currently the most effective weapon in treating falciparum malaria.

The WHO’s announcement describes the plan as a five-step process which “aims to contain and prevent artemisinin resistance by stopping the spread of resistant parasites, increase monitoring and surveillance for artemisinin resistance, improve access to malaria diagnostic testing and rational treatment with ACTs, invest in artemisinin resistance-related research, and motivate action and mobilize resources.”

Global Health Progress is hopeful that this action plan will help to ensure that developing nations continue to have access to drugs that most effectively treat malaria. Many malaria-stricken countries lack the resources needed to keep an effective health care system running smoothly. Strong, effective health systems are vital to helping those in need of access to drugs, and health care improvements made today will strengthen the ability of countries to develop sustainable systems that can meet tomorrow’s challenges. Stopping the spread of drug-resistant strains of malaria and other diseases are essential to these goals.

Investing in local R&D capacity and national research systems is another way research-based biopharmaceutical companies help strengthen health systems. Local production can play a valuable role in building overall local capacity and enabling developing countries to increase access to essential medicines.

It is the responsibility of the entire international community to facilitate access to medicines. Success depends on all sectors working in partnership; not only to make medicines more accessible, but also to ensure continued innovation into new medicines for the treatment and prevention of all diseases.

About Global Health Progress:
Global Health Progress also supports efforts to raise awareness and mobilize resources to address health challenges in the developing world by bringing local leaders together with international health experts, policymakers, donor governments, and the private sector. www.globalhealthprogress.org;  twitter.com/globalhealth; facebook.com/pages/Global-Health-Progress/124850684219049;  linkedin.com/groups?home=&gid=2972068

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Next Genetic Natural Stem Cell Therapy Established

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Division of Gene Medicine & Stem Cell Application, School of Medical Science, complete the research and established completely new protocol totally recovering natural bio mechanism of hair regrowth.

The researchers, led by Lord. Prof. Dr. Daichent Otto Rie, specified protein and genom to affect internal bio mechanism to generate hair and control the level of successful growth being low which is the baldness.

The key cast of the set of the bio cycle is hair follicles, which is stem cell on head skin and effect or holding function to cure many neurotic diseases and disorders like Alzheimer’s disease – Prion Disease and even Trion Disease (Post Hetero-Plastic Implantation Chronic Inflammation Syndrome; PhCIS) has absolutely unique character being retrieved absolute stem cell, which can recover the ability as stem cell after got adult. The key genom and DNA has been found through the Genom Project’s T-Protocol research developing in the government registered Genom Project since 2005. The most concentrated attention of researchers is not “what is cause” but “What protocol is best”.

The team of Prof.Daichent has successfully completed in vivo and in vivro experiment actually using voluntary patients whose types of hair loss being across over highly wide range extent to even lymphoma and cancer and finally established next genetic hair loss curing treatment protocol mainly composed of stem cell therapy and gene therapy.

Most of cases are treatable through entry level stem cell theraputic technique or HIV-1 Vector using high level technique but A20 introduction as gene therapy is required when treating patients being suffered from lymphoma, cancer or any neurotic diseases like Alzheimer’s disease – Prion Disease and even Trion Disease (Post Hetero-Plastic Implantation Chronic Inflammation Syndrome; PhCIS).

As Prof.Daichent points since 2005 being on School of Public Health of Harvard, in the treatment manual (published 2005), the key factor to overcome of lymphoma and chronic inflammation on human skin is extraordinary redundancy coding of polyglutamine DNA synthesis as the type of disease caused by pathological proteins and lack or heavy impairment of an specific DNA of A20.

Actually, the treatment protocol curing for baldness is also found through T-protocol which was essentially aimed at achieving causal and complete treatment of lymphoma, cancer, chronic inflammation and many neurotic diseases.

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Global Health Progress Commends European Union and India Agreement Increasing Access to Drugs in Developing Countries

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According to a Reuter’s article, the European Union (EU) and India have come to an agreement which should ease the process of exporting Indian drug manufacturers’medicines to developing countries, increasing these countries’ access to drugs.

Karel De Gucht, commissioner of the European Union (EU) has confirmed an agreement between the EU and India that will resolve some of the disputes that lead to the seizure of generic drugs in transit last year. This agreement will allow shipments of medication to pass through Europe to developing nations without being checked for anything except counterfeiting.

The new agreement will also amend custom codes allowing shipments of medications from India to reach countries located in South America via Europe. The confirmation comes amid trade talks between the EU and India.

Global Health Progress commends the agreements between the European Union and India, which will increase access to drugs, primarily generic medication, for underdeveloped countries. This process affects the affordability of generic medications to underdeveloped countries which fight the prominence of infectious diseases such as HIV/AIDS and malaria.

Since the 1960s, the philanthropic efforts of research-based biopharmaceuticalcompanies have worked to get medicines to the people that need them the most. In 2005, biopharmaceutical companies responded to requests with more than $3 billion in medical products donated worldwide.

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Global Health Progress Applauds HIV-Prevention Medicine Trial, Encourages Access to Medicines in Developing Countries

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The New England Journal of Medicine recently released the results of a ground-breaking trial of an HIV-prevention method called oral pre-exposure prophylaxis (PrEP). Data from the trial revealed an almost 44 percent reduction of new HIV infections among participants who took the antiretroviral tablet daily to prevent HIV, compared to those who took the placebo pill.

Participants in the study included 2,499 HIV-negative gay men, transgender women, and other men who have sex with men (MSM) from Peru, Ecuador, Brazil, South Africa, Thailand and the United States; these were randomly chosen to receive the antiretroviral (ARV) drug TDF/FTC (brand name Truvada) or a placebo pill. Regular HIV tests were administrated throughout the study. At the end of the trial, 36 participants who took Truvada had become infected, compared to 64 of the participants who took the placebo pill.

Similar trials are currently being conducted among heterosexuals in Africa and injection drug users in Thailand. Additionally, a trial of a similar ARV in gel form is currently being tested in three US cities, Pittsburgh, Boston and Birmingham, Alabama.

Global Health Progress is encouraged by the outcome of this trial, as it could lead to the prevention of HIV in developing countries and around the world. However, additional funding is needed not only to continue developing drugs like this, but to increase access to medicines around the world. As the world of medicine continues to advance, it is the responsibility of the entire international community to facilitate access to medicines. Success depends on all sectors working in partnership; not only to make medicines more accessible, but also to ensure continued innovation into new medicines for the treatment and prevention of all diseases.

Research-based biopharmaceutical companies help the fight against the HIV/AIDS epidemic by providing millions of doses of anti-retroviral drugs at discounted prices and, in some cases, for free to patients in developing countries. These donation programs for Least Developed Countries and sub-Saharan Africa, together with programs for lower and middle income countries, apply to more than 87 percent of all people living with HIV/AIDS worldwide.

About Global Health Progress:
Global Health Progress also supports efforts to raise awareness and mobilize resources to address health challenges in the developing world by bringing local leaders together with international health experts, policymakers, donor governments, and the private sector. www.globalhealthprogress.org; twitter.com/globalhealth;facebook.com/pages/Global-Health-Progress/124850684219049; linkedin.com/groups?home=&gid=2972068

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Molplex Launches Novel ‘Drug Discovery On Demand’ Service

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An innovative new online “drug discovery on demand” platform has been launched by Molplex, a company specializing in products and services for the life sciences. Designed to help drug discovery groups working anywhere in the world, it aims to eliminate the high start-up costs and minimize the financial risks traditionally associated with inventing new medicines.

Molplex CEO David Leahy said: “As the pharmaceutical industry changes, a new ecosystem of small, flexible teams operating as “Micro Pharmas” is emerging. Molplex will provide the services they need to succeed at inventing better medicines at lower cost”.

The first version of the new Molplex system launched today offers free access to sophisticated drug design systems, high quality assay-ready stock chemicals and high content biological screening at www.molplex.com.

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Global Health Progress Amplifies New Report that Outlines Barriers in Securing Access to Medicines in Least Developed Countries

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“There is a public health crisis in the least developed countries. It is a crisis made by humans and solvable only by humans. There is urgency for governments, businesses, NGOs and academia to collaborate in dealing with this most urgent of problems,” declares Cameron Institute’s new 200-page report, Pharmaceutical Access in Least Developed Countries: on-the-ground barriers and industry successes.

Executive Director D. Wayne Taylor, Ph.D., F.CIM., who prepared the report, cites the recent World Health Organization’s (WHO) Draft Global Plan and Strategy for Action in stressing the importance of pharmaceutical industry partnerships. The report states that the industry must focus its energies on “the growing burden of diseases and conditions that disproportionately affect developing countries, and particularly women and children.”

Global Health Progress actively supports the report’s outlined actions needed to solve this issue, including endorsement of public-private partnerships (PPPs), protecting intellectual property and drug patents as the cornerstones of affordable innovation, improving access to medicines and developing new drugs.

Public-private partnerships are one key way to improve access to medicines in the least developed countries. As the report notes, the research-based pharmaceutical industry, in various public-private partnerships, has been improving access to medicines in the least developed countries of the world since the 1950’s. To date, there have been 150 public-private partnerships whose aim it is to improve access to medicines and currently 90% of PPPs are industry-led.

Additionally, innovation is cited by the report as “the hallmark of the pharmaceutical industry. Without innovation there would be no immunizations,
medicines or biologics to save lives, improve quality of lives, and to save much needed healthcare dollars. A basic right in law is to retain possession of one’s own ideas and discoveries.” The report also notes the importance of protecting this innovation through intellectual property and drug patents, as well as through the infrastructure and legal structures needed for healthy growth.

The report adds that every dollar invested in new medicines relieves the healthcare system of seven dollars of expenditure elsewhere, and that new drugs increase life expectancy and life-time income by about 1.0% per year while also decreasing years of life lost. It also provides a summary of 2010 data regarding contributions provided by research-based pharmaceutical industry to least developed countries:

• USD 8,450,000,000 of product and investment
• 950,000,000 patients treated
• 9,500,000,000 doses/treatments administered
• 350,000 doctors, nurses and other health personnel trained

Despite this progress, actions are still needed to solve the problem without creating additional difficulties. For example, even though existing medicines for HIV/AIDS has reduced mortality rates in developed countries by 70%, adherence and compliance are two major obstacles, amongst many, to the successful deployment of these drugs in developing countries. Additional barriers to access and improved health in least-developed countries include “on the ground” barriers, such as market failure, corruption, non-existent health human resources and infrastructure, and the lack of both local and international political will.

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Fact Sheet Reveals Mexico’s Increasing Investment in Biopharmaceutical Sector

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A recent Global Health Progress fact sheet highlights how Mexico’s investment in its biopharmaceutical sector has spurred economic growth, fostered global competitiveness, reduced the health and economic burden of disease on local citizens, and improved access to medicines. With the tenth largest economy in the world, Mexico is currently investing more than 1% of its gross domestic product into its biopharmaceutical sector and this percentage is anticipated to increase as the country works to develop tomorrow’s medicines.

Like the U.S. and other big emerging markets, Mexico has recognized the potential of the biopharmaceutical sector to be an important source of economic growth through the creation of high-quality, high-skilled jobs. Currently, Mexico’s biopharmaceutical sector employs nearly 25,000 Mexican nationals at more than 32 biotechnology companies. The number of skilled workers entering the workforce is predicted to increase as more than 750,000 engineering and technology students in Mexico are currently enrolled in local universities. Additionally, collaboration between the public and private sector has resulted in the creation of more than 100 research centers.

Mexico’s emphasis on job creation stimulates the developments of new drugs, which improves access to medicines for its entire citizenry. For example, there are approximately 254 medicines in development or awaiting regulatory review for Mexican patients and Mexico currently ranks 19 out of 25 in terms of active clinical trial sites. The growth in share of global clinical trial sites can bring health benefits to Mexican patients, such as diffusion of medical knowledge, greater patience access to medicines and high quality care and effective medical practice.

Recognizing the potential for economic growth, improving access to medicines and inspiring drug innovation, the Mexican government has sought to implement policies to foster the growth of the sector. The National Council for Science and Technology, the principal government funding agency for scientific research in Mexico, provided approximately US $16 million to fund basic science projects between 2001 and 2004. Mexico also has several bioclusters, made up of biotechnology, biopharmaceutical and related companies, focused on pharmaceutical R&D. In addition, public-private partnerships between the Mexican government, academia and industry are increasing due in part to the government’s continued commitment to science and technology research and education.

Please view full PDF for additional information and list of sources.

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Global Health Progress Fact Sheet Projects China Will Become One of World’s Major Biopharmaceutical Players

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Data revealed in Global Health Progress’ (GHP) new fact sheet shows that China is projected to become one of the world’s major biopharmaceutical players, along with the U.S., Europe, and Japan, in the next fifteen years. This projection is based on China’s commitment to improving access to healthcare by expanding its biotechnology sector, increasing its exportation of biopharmaceuticals and investing in pharmaceutical research and development (R&D).

China has one of the fastest growing economies in the world with a gross domestic product of more than $8 trillion. Its biotechnology sector has become a bright spot in the Asia Pacific region and the world markets, with an impressive average annual growth rate of 19.4% between 2000 and 2005, and is anticipated to become the world’s third-largest pharmaceutical market in 2011, a major increase over its #8 rank in 2000

Part of China’s successful growth is due to its decision to improve access to healthcare by increasing exports of biopharmaceuticals. For example, in 2006 China exported a total of US $890 million in biopharmaceuticals – a 30.61% increase compared with the previous year. China has also become the largest vaccine manufacturing country in the world, capable of producing 41 vaccines to prevent 26 viral diseases, and has become the third country to succeed in large-scale production of genetically engineered insulin.

Additionally, China’s pharmaceutical R&D expenditures are expected to reach US $10 billion or 2% of global spending by the end of 2010. The country is expected to contribute an additional $40+ billion in annual sales by 2013, comparable to the level of increased sales forecast for the US market in the same period.

China’s investment in the biotechnology sector has translated into improvements regarding access to healthcare and the country’s economic growth through creating high-quality, highly skilled jobs. Currently, there are more than 500 biotechnology companies in China with the biopharmaceutical sector employing approximately 50,000 people. Additionally, pharmaceutical R&D is taking the form of multinational biopharmaceutical companies setting up research facilities in biotechnology parks in China, which can drive highly-skilled, high wage job growth and encourage better access to healthcare.

Please view full PDF for additional information and list of sources.

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